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General Disclaimer

These programs are free software; you can redistribute them and/or modify them under the terms of the GNU General Public License (GPL) as published by the Free Software Foundation.

This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.

See the GNU General Public License for more details.

Organization of Code

.ssc files

An ssc (S-Plus script) file contains S-Plus code, either commands that will be run or declarations of functions that need to be called to run. Under S-Plus for Windows Version 2000 and 6.0, double-click on the ssc file to start up S-Plus and have the code available in the script window. Code can be selected and run from there.

SSC files contain S-Plus expressions in a human readable format.

Under S-Plus for Unix (including Linux), use source("filename.ssc") to read in the file, or use an editor and copy/ paste to execute selected commands.

.sdd files

An sdd (S-Plus data dump) file can contain one or more S-Plus objects, even an entire working directory's contents. Using data.restore("filename.sdd") will read in all objects. No code will be executed, but objects will be created that might overwrite existing objects of the same name.

SDD files are not easily read by a human being

It is a good idea to look at the code first before you read it in and run commands.

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Introduction
1	Rodda, Millard, and Krause
	Statistics and the Drug Development Process
Basic Research and Preclinical Studies
2	Pikounis
	One-Factor Comparative Studies
Pre-Clinical Safety Assessment
3	Ahn and Kodell
	Analysis of Animal Carcinogenicity Data
4	Hoffman, Heathman, Chou, and Allen
	Analysis of Toxicokinetic and Pharmacokinetic Data from Animal Studies
Phase I
5	Nguyen and Amaratunga
	Analysis of Pharmacokinetic Studies
6	Bock
	Graphical Presentation of Single Patient Results
7	Pikounis, Bradstreet, and Millard
	Graphical Insight and Data Analysis for the 2, 2, 2 Crossover Design
8	Benner, Edler, and Hartung
	Design and Analysis of Phase I Cancer Treatment Trials
9	Wang
	Patient Compliance and Its Impact on Steady State Pharmacokinetics
10	Ette, Lockwood, Miller, Mandema
	Analysis of Analgesic Trials
Phase II and III
11	Bock
	Power and Sample Size Calculations
12	Jahn
	Comparing Two Treatments in a Large Phase III Trial
13	Olson
	Using S-Plus and SAS for ANOVA and Contrasts
14	Berger and Ivanova
	Permutation Tests in S-PLUS for in Phase III Clinical Trials
15	Wang and Krause
	Sample Size Re-Estimation in Clinical Trials
16	O'Rourke, Shea, and Wells
	Meta Analysis in Clinical Trials
Phase IV
17	Cook, Carides, and Dasbach
	Analysis of Health Economic Data
Manufacturing and Production
18	Eisele, Gasparini, and Racine
	Evaluation of the Decimal Reduction Time of a Sterilization Process in Pharmaceutical Production
19	Yang and Carlin
	Acceptance Sampling Plans By Attributes

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